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1 edition of Zanamivir for the treatment of influenza in adults found in the catalog.

Zanamivir for the treatment of influenza in adults

Zanamivir for the treatment of influenza in adults

a systematic review and economic evaluation

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Published by Core Research on behalf of the NCCHTA in Alton .
Written in English


Edition Notes

Includes bibliographical references.

StatementA. Burls ... [et al.].
SeriesHealth technology assessment -- v.6, no.9
ContributionsBurls, Amanda., National Co-ordinating Centre for HTA (Great Britain), Health Technology Assessment Programme.
The Physical Object
Paginationiv, 87p. :
Number of Pages87
ID Numbers
Open LibraryOL19809424M

  INTRODUCTION. Three classes of antiviral drugs are available for the prevention and/or treatment of influenza: The neuraminidase inhibitors, zanamivir, oseltamivir, and peramivir, which are active against both influenza A and influenza B. The selective inhibitor of influenza cap-dependent endonuclease, baloxavir, which is active against influenza A and B.   Bearman GM, Shankaran S, Elam K. Treatment of severe cases of pandemic (H1N1) influenza: review of antivirals and adjuvant therapy. Recent Pat Antiinfect Drug Discov. .

Herein we evaluated the antiviral effects of zanamivir in relationship with clinical efficacy in a subset of adolescents and adults with naturally occurring influenza A virus infections. Drug susceptibility and genotypic studies were also done on serial isolates recovered during treatment for assessing the emergence of viral resistance.   The respective reported mean values of inhibitory concentrations of 50% of zanamivir and oseltamivir were and nmol/L for influenza A/H1N1, and nmol/L for influenza A/H3N2, and and nmol/L for influenza B [].These findings may explain our results from a clinical context, because they reveal that oseltamivir is slightly more effective against influenza .

During prolonged treatment with zanamivir, a mutant strain of influenza B was isolated from an immunocompromised child. Influenza viruses are classified into 3 distinct types, influenza A, influenza B, and influenza C. Influenza A is further divided into subtypes based on their hemagglutinin (H or HA) and neuraminidase (N or NA) activity. E. Paintsil, Yung-Chi Cheng, in Encyclopedia of Microbiology (Third Edition), Clinical indications. Zanamivir and oseltamivir are used for treatment and prevention of influenza A and B infections. Treatment of otherwise healthy adults and children with zanamivir and oseltamivir reduces the duration of symptoms by and 1 days, and provides 29–43% relative reduction in the odds of.


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Zanamivir for the treatment of influenza in adults Download PDF EPUB FB2

Prophylaxis studies. Zanamivir has several studies evaluating its use as a prophylactic agent for influenza in children and adults. The first double-blind trial randomized adults (18–64 years) to zanamivir (10 mg daily) or placebo for 4 weeks at the start of the influenza season (Monto et al ).The most prominent virus of was A/Sydney/5/97 (H3N2) which was not in the annual Cited by:   For treatment of adults, zanamivir reduced the time to first alleviation of symptoms of influenza-like illness by days (95% confidence interval toP.

For treatment of adults, zanamivir reduced the time to first alleviation of symptoms of influenza-like illness by days (95% confidence interval toPCited by:   Inhaled zanamivir, a potent and selective inhibitor of influenza A and B virus NAs, has been demonstrated to be effective for acute influenza treatment and for prophylaxis.

A previous study was conducted in families in which the first case patient was treated and the rest of the household was given prophylaxis [ 7 ].Cited by:   Adults. Zanamivir. Inhaled zanamivir is FDA-approved for treatment of adults with uncomplicated acute illness caused by influenza A or B virus, and for chemoprophylaxis of influenza among adults.

Zanamivir is not recommended for persons with underlying airways disease (e.g., asthma or chronic obstructive pulmonary diseases) [].

on the use of zanamivir, oseltamivir and amantadine for the treatment of influenza'(NICE technology appraisal guidance 58). Accurate monitoring of influenza activity requires analysis of clinical, virological and epidemiological information.

The management of influenza is supportive and consists of relieving symptoms while awaiting recovery. Zanamivir is an antiviral medicine that blocks the actions of viruses in your body.

Zanamivir is used to treat flu symptoms caused by influenza virus in people who have had symptoms for less than 2 days.

Zanamivir may also be given to prevent influenza in people who may be exposed but do not yet have symptoms. Safety and Pharmacokinetics of Intravenous Zanamivir Treatment in Hospitalized Adults With Influenza: An Open-label, Multicenter, Single-Arm, Phase II Study Francisco M.

Marty, 1 Choy Y. Man, 2 Charles van der Horst, 5 Bruno Francois, 6 Denis Garot, 7 Rafael Máňez, 8 Visanu Thamlikitkul, 11 José A. Lorente, 10 Francisco Álvarez. Inthe FDA approved zanamivir and oseltamivir for the treatment of uncomplicated acute influenza A or B in patients who have been symptomatic for.

Peramivir is a novel cyclopentane neuraminidase inhibitor of influenza virus. It was approved by the Food and Drug Administration in December for treatment of acute uncomplicated influenza in patients 18 years and older.

For several months prior. Zanamivir is a medication used to treat and prevent influenza caused by influenza A and B is a neuraminidase inhibitor and was developed by the Australian biotech firm Biota Holdings.

It was licensed to Glaxo in and approved in the US inonly for use as a treatment for influenza. Init was approved for prevention of influenza A and B. Zanamivir was the first. INDICATIONS Treatment Of Influenza. RELENZA ® (zanamivir) inhalation powder is indicated for treatment of uncomplicated acute illness due to influenza A and B virus in adults and pediatric patients aged 7 years and older who have been symptomatic for no more than 2 days.

Prophylaxis Of Influenza. RELENZA is indicated for prophylaxis of influenza in adults and pediatric. Results from a study investigating intravenous (IV) zanamivir for the treatment of hospitalized infants and children with influenza are presented. METHODS: This phase II, open-label, multicenter, single-arm study assessed the safety of investigational IV zanamivir in hospitalized children with influenza.

Treatment of Influenza • The recommended dose of RELENZA for treatment of influenza in adults and pediatric patients aged 7 years and older is 10 mg twice daily (approximately 12 hours apart) for 5 days. • Two doses should be taken on the first day of treatment whenever possible provided there is at least 2 hours between doses.

Zanamivir and oseltamivir are used for treatment and prevention of influenza A and B infections. Treatment of otherwise healthy adults and children with zanamivir and oseltamivir reduces the duration of symptoms by and 1 days, and provides 29–43% relative reduction in the odds of complications when given within 48 h of onset of symptoms.

For treatment of adults, zanamivir reduced the time to first alleviation of symptoms of influenza-like illness by days (95% confidence interval toP.

influenza symptoms when used for treatment of outpatient adults with uncomplicated influenza by about 1 day (Kohno, ); similar benefit was shown in clinical trials when a single dose of peramivir was given by intramuscular injection for treatment of uncomplicated influenza in adults (Whitley, ).

On December During the United States – influenza season, increasing incidence of drug resistance by strain H3N2 to amantadine and rimantadine led the CDC to recommend oseltamivir as a prophylactic drug, and the use of either oseltamivir or zanamivir as treatment.

Over-the-counter medication. Randomized controlled trials testing the effects of zanamivir for prophylaxis, postexposure prophylaxis (PEP), and treatment of influenza were included in the study. The primary outcome of this study was the time to alleviation of symptoms of influenza-like illness.

For adults, the alleviation of symptoms was by days (p. It is possible that some influenza viruses may become less susceptible or resistant to oseltamivir and peramivir during antiviral treatment with one of these drugs and remain susceptible to zanamivir; this has been reported most often for influenza A(H1N1)pdm09 viruses (Graitcer, ; Lackenby, ; Memoli, ; Nguyen, ; Nguyen.

Action and uses of zanamivir Zanamivir is a new treatment of influenza (flu) A/B licensed for use in adults and adolescents who present with clear symptoms of infection during the flu season. It is a selective inhibitor of viral neuraminidase enzyme which is necessary for the release of newly formed virus from the surface of infected host cells.More clinical data are available concerning the effectiveness of zanamivir and oseltamivir for treatment of influenza A infection than for treatment of influenza B infection.

However, in vitro data () and data from treatment in mice and ferrets (26,27,30,31) document that zanamivir and oseltamivir have activity against influenza B viruses.Hayden FG, Gubareva LV, Monto AS, et al; Zanamivir Family Study Group.

Inhaled zanamivir for the prevention of influenza in families. Zanamivir Family Study Group. N Engl J Med. Nov 2. (18) Randomised trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections.